Rapid tolerance to the hypotensive effects of glyceryl trinitrate in the rat: prevention by N-acetyl-l- but not N-acetyl-d-cysteine
نویسندگان
چکیده
منابع مشابه
Effects of N-acetyl-L-cysteine on Postoperative Intrabdominal Adhesion in a Large Animal Model
Objective- Mechanisms that decrease oxidative stress and enhance peritoneal fibrinolysis reduce adhesions. N-acetyl-L-cysteine (NAC) is an antioxidant whose effect on peritoneal fibrinolysis in large animal model has not been established. The aims of this study were to investigate the ability of NAC to decreased adhesion in stablished model of serosal trauma in sheep. Design- Expe...
متن کاملSeparation and quantification of N-acetyl-l-cysteine and N-acetyl-cysteine-amide by HPLC with fluorescence detection.
N-acetyl-l-cysteine (NAC) is a well-known antioxidant that is capable of facilitating glutathione (GSH) biosynthesis and replenishing intracellular GSH under oxidatively challenging circumstances. N-acetyl-cysteine-amide (NACA), the amide form of NAC, is a newly designed and synthesized thiol-containing compound which is believed to be more lipophilic and permeable through cell membranes than N...
متن کاملThe Efficacy of N-Acetyl-Cysteine (NAC) Supplementation in FST Model for Screening Antidepressants
Introduction: The model for screening antidepressant-like activity in pre-clinical drug studies include, rat forced swimming test (FST). The reports on N-acetylcysteine (NAC) as an antioxidant supplement in stress related disorder is well documented. This study was aimed at potential antidepressant mechanism of N- Acetyl Cysteine (NAC), a glutamate precursor on FST animal model for screening an...
متن کاملN-Acetyl L-Cysteine does not protect mouse ears from the effects of noise*
BACKGROUND Noise-induced hearing loss (NIHL) is one of the most common occupational injuries in the United States. It would be extremely valuable if a safe, inexpensive compound could be identified which protects worker hearing from noise. In a series of experiments, Kopke has shown that the compound N-acetyl-L-cysteine (L-NAC) can protect the hearing of chinchillas from the effects of a single...
متن کاملthe effect of n-acetyl cysteine on laryngopharyngeal reflux.
laryngopharyngeal reflux (lpr) is a variant of gastroesophageal reflux disease (gerd) in which the stomach contents go up into the pharynx and then down into the larynx. lpr causes a wide spectrum of manifestations mainly related to the upper and the lower respiratory system such as laryngitis, asthma, chronic obstructive pulmonary disease, cough, hoarseness, postnasal drip disease, sinusitis, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1990
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1990.tb13014.x